Product Name :
PA26 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
1110002G11Rik antibody AU044290 antibody MGC118148 antibody MGC138241 antibody MGC142129 antibody OTTMUSP00000022799 antibody p53 activated gene 26 antibody p53 regulated PA26 nuclear protein antibody p53 regulated protein PA26 antibody p53-regulated protein PA26 antibody 展开
Function :
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human SESN1/PA26 401-492/492
Species reactivity:
Human, Mouse, Rat, Dog, Cow, Horse, Sheep
Verify application:
WB, ELISA, IHC-P, FC, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.Formula of 4-Chloropyridazin-3-ol Avoid repeated freeze/thaw cycles.Ethyl 2-amino-5-methoxynicotinate uses The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.PMID:33461372 When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
57 KDa
Positive control :
Widely expressed.